Apoptosis Animation
Video Overview & Insights
https://xvivo.com/examples/apoptosis-and-bcl-2-2/
watched this in order to get some study dnoe, and im left impressed with a possibile cure for cancer XD, good job lads! :D
ABT-199/GDC-0199 is a small molecule drug in co-development by Abbvie and Genentech for the selective inhibition of BCL-2, a key regulator of cellular apoptosis. BCL-2, part of the larger BCL-2 family, is responsible for the sequestration of pro-apoptopic proteins along the mitochondrial membrane. Displacement of these proteins from BCL-2 in cancerous cells may prime these cells for apoptosis.
satisfying to see these cancer cells die by apoptosis cascades
More User Perspectives
Hope this helps to anyone wondering what is shown here:
1. Cells need to alter their homeostasis towards apoptosis.
2. This is done only after detecting certain signals, such as stress.
3. These signals lead cells to produce proapoptotic proteins called 'BIM'
4. BIM bind with proteins in the Bcl-2 family.
5. This binding induce Bcl-2 to release another set of proapoptotic proteins into the cytoplasm.
6. Freed proapoptotic proteins are allowed to form complexes that punch pores on the outer mitochondrial membrane.
7. This lets cytochrome C leak out of the mitochondria into the cytoplasm.
8. APAF-1 binds cytoplasmic cytochrome C. Let's call this "complex A".
9. Complex A oligomerises [with other A complexes], forming the apoptosome.
10. The apoptosome activates caspases via proteolysis.
11. Also through proteolysis, activated caspases degrade vital structures for the cell.
12. The cell dies
13. This means that Bcl-2 is an antiapoptotic repressor, hence an oncoprotein.
14. Cancer cells overexpress this protein to avoid activation of the intrinsic pathway.
15. This company has made a protein that resembles the proapoptotic proteins mentioned in point 5, allowing them to oligomerise and so on.
So this is an ad, not an educational video.
@outerrealmWould have been a good video if you’d used a real voice. Have to give thumbs down for the AI.
@outerrealmSUBHAN ALLAH
@MRGAMER-lg2pethanks
@Fatima-ls9btThey gotta use a cancer cell as an example so we don’t feel bad for it.
@soldirix2666So the cause is stress.
@AnonyMous-rr4gfThanks for your hard work ❤
@sss_p33p22I’m just curious if this will damage non-cancer cells too?
@milad.nikzadBeautiful animation, Thankss
@rahulbalaji3059What a SUPERCLEAR animation!!
@나는강아지-w6xIt's a great summary elucidate the Apoptosis
@drdavidhakeem6278Does everyone has bcl-2 cells? Or if someone is positive for bcl -2 cell means thar person has cancer?
@Hiitsme1.9Nice video!
@chx99I had to look it up after I heard this. But apparently it can be pronounced with or without the P. With is the most common. However... Neither accepted pronunciation starts with a long a. It's starts with ap- as in apple. (ˌa-pəp-ˈtō-səs)
@WDCallahanDeixa eu ver se entendi. Isso aí destroi o câncer? Ou sou burro?
@moises_matheusExcelentes animaciones y mucho trabajo detrás. He tratado de avanzar con temas de apoptosis y desarrollo embrionario y me resultó extremadamente difícil con los vaivenes que hay en la Ciencia Argentina...
@MBEspinosaAPOTOSIS
@spliceosomeHigh quality piece of work!
@Rokinso